She is married to jazz guitarist John Pizzarelli, and they have a daughter, Madeleine.
Along with her husband John Pizzarelli, Jessica hosts a weekly national radio program called Radio Deluxe.
She has appeared in a dozen Broadway shows such as the revival of Sunday in the Park With George and Cats and has premiered theater pieces off-Broadway, including the Jason Robert Brown 1995 musical Songs for a New World, and in regional theaters across the US.